Issue 6, 2012
From the journal:

RSC Advances

Synthesis, characterization and cytotoxicity study of magnetic (Fe3O4) nanoparticles and their drug conjugate

Biswadip Banerji,*a   Sumit Kumar Pramanik,a   Samir Mandal,b   Nakul Chandra Maitic  and  Keya Chaudhurib  

* Corresponding authors

a Department of Chemistry, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata, India
E-mail: biswadip@iicb.res.in, biswadip.banerji@gmail.com
Fax: (+)91 33 24735197
Tel: (+)91 33 24995709

b Molecular & Human Genetics Division, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata, India

c Structural Biology & Bioinformatics Division, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata, India

Abstract

An easy synthesis of magnetic nanoparticles (Fe3O4) is described. Transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS) and X-ray diffraction (XRD) have been used to study the well dispersed and uniformly spherical nanoparticles. 5-Fluorouracil (5-FU) has been successfully loaded onto the nanoparticles and cytotoxicity studies were performed using a standard MTT assay. The results indicate that 5-fluorouracil-loaded iron nanoparticles are a more potent anticancer drugversus5-fluorouracil alone.

Graphical abstract: Synthesis, characterization and cytotoxicity study of magnetic (Fe3O4) nanoparticles and their drug conjugate

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Article information

DOI
https://doi.org/10.1039/C2RA01118B
Article type
Paper
Submitted
17 Nov 2011
Accepted
11 Dec 2011
First published
02 Feb 2012

RSC Adv., 2012,2, 2493-2497

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Synthesis, characterization and cytotoxicity study of magnetic (Fe3O4) nanoparticles and their drug conjugate

B. Banerji, S. K. Pramanik, S. Mandal, N. C. Maiti and K. Chaudhuri, RSC Adv., 2012, 2, 2493 DOI: 10.1039/C2RA01118B

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