Issue 4, 2011
From the journal:

RSC Advances

Three-component solvent-free synthesis of highly substituted tetra-hydroimidazo[1,2-a]pyridines†

Fuchao Yu,‡a   Shengjiao Yan,‡a   Rong Huang,a   Yajuan Tanga  and  Jun Lin*a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
E-mail: linjun@ynu.edu.cn
Fax: +86 871 5033215
Tel: +86 871 5033215

Abstract

An efficient and green method has been developed for the synthesis of tetrahydroimidazo[1,2-a]pyridines by three-component reactions of heterocyclic ketene aminals (HKAs), triethoxymethane and nitroalkenes in one pot in the absence of catalyst and solvent. This protocol has advantages of environmental friendliness, high yields (73–93%), short reaction time and convenient operation.

Graphical abstract: Three-component solvent-free synthesis of highly substituted tetra-hydroimidazo[1,2-a]pyridines

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Article information

DOI
https://doi.org/10.1039/C1RA00242B
Article type
Paper
Submitted
29 May 2011
Accepted
27 Jun 2011
First published
17 Aug 2011

RSC Adv., 2011,1, 596-601

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Three-component solvent-free synthesis of highly substituted tetra-hydroimidazo[1,2-a]pyridines

F. Yu, S. Yan, R. Huang, Y. Tang and J. Lin, RSC Adv., 2011, 1, 596 DOI: 10.1039/C1RA00242B

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