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Issue 13, 2020
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Regio- and stereoselective halothiolation of alkynes using lithium halides and N-thiosuccinimides

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Abstract

We have developed a highly regioselective halothiolation of alkynes under simple and mild conditions. Our halothiolation reagents are readily available alkali metal halides and N-thiosuccinimides. Our transition metal-free system offers good chemical yields for a wide range of alkyne substrates with satisfactory regioselectivity and good functional group tolerance.

Graphical abstract: Regio- and stereoselective halothiolation of alkynes using lithium halides and N-thiosuccinimides

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Article information


Submitted
10 Apr 2020
Accepted
20 May 2020
First published
28 May 2020

Org. Chem. Front., 2020,7, 1690-1695
Article type
Research Article

Regio- and stereoselective halothiolation of alkynes using lithium halides and N-thiosuccinimides

S. Liu, X. Zeng and B. Xu, Org. Chem. Front., 2020, 7, 1690
DOI: 10.1039/D0QO00367K

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