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Issue 6, 2020
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Cu2O-catalyzed selective 1,2-addition of acetonitrile to α,β-unsaturated aldehydes

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Abstract

A cyanomethylation of α,β-unsaturated aldehydes with acetonitrile as a nucleophile is disclosed. The reaction is promoted with Cu2O as an inexpensive catalyst. Mild conditions are used, and the reaction completes within a few minutes. Through our simple and scalable operation, a large set of δ,γ-unsaturated-β-hydroxyl nitriles are prepared in good to high yields.

Graphical abstract: Cu2O-catalyzed selective 1,2-addition of acetonitrile to α,β-unsaturated aldehydes

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Article information


Submitted
13 Jan 2020
Accepted
15 Feb 2020
First published
19 Feb 2020

Org. Chem. Front., 2020,7, 868-872
Article type
Research Article

Cu2O-catalyzed selective 1,2-addition of acetonitrile to α,β-unsaturated aldehydes

F. Che, M. Wang, C. Yu, X. Sun, D. Xie, Z. Wang and Y. Zhang, Org. Chem. Front., 2020, 7, 868
DOI: 10.1039/D0QO00024H

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