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Issue 13, 2020
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Palladium-catalyzed ortho-selective C–H hydroxylation of carboxybenzyl-protected benzylamines

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Abstract

A convenient approach to synthesize o-hydroxybenzylamine via Pd-catalyzed hydroxylation of benzylamine with a removable Cbz-amide as the directing group was developed. Various functional groups were well tolerated, leading to various substituted o-hydroxybenzylamines in moderate to good yields.

Graphical abstract: Palladium-catalyzed ortho-selective C–H hydroxylation of carboxybenzyl-protected benzylamines

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Article information


Submitted
23 Dec 2019
Accepted
01 Jun 2020
First published
02 Jun 2020

Org. Chem. Front., 2020,7, 1703-1708
Article type
Research Article

Palladium-catalyzed ortho-selective C–H hydroxylation of carboxybenzyl-protected benzylamines

C. Dai, Y. Han, L. Liu, Z. Huang, D. Shi and Y. Zhao, Org. Chem. Front., 2020, 7, 1703
DOI: 10.1039/C9QO01523J

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