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Issue 10, 2020
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Straightforward access to densely substituted chiral succinimides through enantioselective organocatalyzed Michael addition of α-alkyl-cyclic ketones to maleimides

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Abstract

A simple organocatalytic system provides efficient access to a series of densely substituted chiral succinimides bearing a quaternary–tertiary carbon stereocenter sequence in good yields, with high diastereo- and enantioselectivities through enantioselective conjugate addition of unreactive α-alkyl cyclic ketones to maleimides under microwave-assisted conditions.

Graphical abstract: Straightforward access to densely substituted chiral succinimides through enantioselective organocatalyzed Michael addition of α-alkyl-cyclic ketones to maleimides

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Article information


Submitted
11 Dec 2019
Accepted
06 Feb 2020
First published
13 Feb 2020

Org. Chem. Front., 2020,7, 1224-1229
Article type
Research Article

Straightforward access to densely substituted chiral succinimides through enantioselective organocatalyzed Michael addition of α-alkyl-cyclic ketones to maleimides

L. Wei, L. Chen, F. Le Bideau, P. Retailleau and F. Dumas, Org. Chem. Front., 2020, 7, 1224
DOI: 10.1039/C9QO01463B

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