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Issue 21, 2019
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Cu-Catalysed carboxylation of aryl boronic acids with CO2

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Abstract

A copper/N-heterocyclic carbene (NHC) catalysed carboxylation of aryl boronic acids under one atmospheric pressure of CO2 has been developed. A wide range of aryl boronic acids was transformed into benzoic acid derivatives in moderate to high yields. The carboxylation method shows excellent functional group compatibility, and sensitive functional groups such as carbonyls, esters, and nitriles were tolerated. Mechanistic studies revealed the vital role of the base in promoting the transmetalation step for this copper-catalysed carboxylation.

Graphical abstract: Cu-Catalysed carboxylation of aryl boronic acids with CO2

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Supplementary files

Article information


Submitted
18 Aug 2019
Accepted
17 Sep 2019
First published
23 Sep 2019

Org. Chem. Front., 2019,6, 3673-3677
Article type
Research Article

Cu-Catalysed carboxylation of aryl boronic acids with CO2

O. S. Nayal, J. Hong, Y. Yang and F. Mo, Org. Chem. Front., 2019, 6, 3673 DOI: 10.1039/C9QO01023H

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