A [4 + 1] annulation of ortho-electrophile-substituted para-quinone methides for the synthesis of indanes and isoindolines

Abstract

A [4 + 1] annulation between newly designed ortho-electrophile-substituted para-quinone methides and nucleophiles through tandem 1,6-conjugated addition/1,4-Michael addition under mild reaction conditions has been described. This reaction provides an efficient method to construct indanes and isoindolines in moderate to good yields and with good functional group tolerance.