Issue 15, 2019

Synthesis of 1-aminoindole derivatives via Rh(iii)-catalyzed annulation reactions of hydrazines with sulfoxonium ylides

Abstract

Rhodium(III)-catalyzed C–H functionalization followed by intramolecular annulation reactions between hydrazines and sulfoxonium ylides is described. This protocol leads to the efficient formation of 1-aminoindole derivatives with a broad substrate scope. A high level of chemoselectivity and functional group tolerance of this transformation were also observed.

Graphical abstract: Synthesis of 1-aminoindole derivatives via Rh(iii)-catalyzed annulation reactions of hydrazines with sulfoxonium ylides

Supplementary files

Article information

Article type
Research Article
Submitted
17 Apr 2019
Accepted
06 Jun 2019
First published
13 Jun 2019

Org. Chem. Front., 2019,6, 2662-2666

Synthesis of 1-aminoindole derivatives via Rh(III)-catalyzed annulation reactions of hydrazines with sulfoxonium ylides

W. Xie, X. Chen, J. Shi, J. Li and R. Liu, Org. Chem. Front., 2019, 6, 2662 DOI: 10.1039/C9QO00524B

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