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Issue 5, 2019
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One-pot, three-component approach to diarylacetonitriles

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Described herein is a novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF3-OEt2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, is also demonstrated.

Graphical abstract: One-pot, three-component approach to diarylacetonitriles

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The article was received on 28 Dec 2018, accepted on 18 Jan 2019 and first published on 18 Jan 2019

Article type: Research Article
DOI: 10.1039/C8QO01419A
Org. Chem. Front., 2019,6, 669-673

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    One-pot, three-component approach to diarylacetonitriles

    D. K. Singh, S. S. Prasad, J. Kim and I. Kim, Org. Chem. Front., 2019, 6, 669
    DOI: 10.1039/C8QO01419A

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