Issue 8, 2019

Neglected sulfur(vi) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

Abstract

Historically, sulfoximines, sulfondiimines and sulfonimidamides have been neglected pharmacophores in drug discovery even though they offer very interesting properties. This highlight shares the key learnings of various lead optimization approaches at Bayer AG that have successfully utilized these neglected sulfur(VI) functional groups to deliver multiple clinical candidates. In this context, the key synthetic methods utilized for the synthetic preparation of these unusual compounds will be outlined.

Graphical abstract: Neglected sulfur(vi) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

Article information

Article type
Highlight
Submitted
13 Nov 2018
Accepted
13 Dec 2018
First published
22 Mar 2019
This article is Open Access
Creative Commons BY-NC license

Org. Chem. Front., 2019,6, 1319-1324

Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

U. Lücking, Org. Chem. Front., 2019, 6, 1319 DOI: 10.1039/C8QO01233D

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