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Issue 4, 2019
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Room-temperature Pd(II)-catalyzed direct C–H TIPS-ethynylation of phenylacetic amides with terminal alkynes

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Abstract

Ligand-promoted room-temperature Pd(II)-catalyzed direct C–H alkynylation of phenylacetic amides has been developed using commercially available TIPS-acetylene as an efficient alkynylating reagent, where 8-aminoquinoline was employed as a removable bidentate auxiliary, thus giving rise to optically pure ortho-alkynylated α-APA in a highly efficient manner.

Graphical abstract: Room-temperature Pd(ii)-catalyzed direct C–H TIPS-ethynylation of phenylacetic amides with terminal alkynes

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Publication details

The article was received on 09 Nov 2018, accepted on 10 Dec 2018 and first published on 11 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QO01215F
Org. Chem. Front., 2019,6, 442-446

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    Room-temperature Pd(II)-catalyzed direct C–H TIPS-ethynylation of phenylacetic amides with terminal alkynes

    C. Chen, Y. Chai, Z. Zhou, W. Rao, B. Liu, L. Liu, R. Xu, Y. Liu and M. Zeng, Org. Chem. Front., 2019, 6, 442
    DOI: 10.1039/C8QO01215F

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