Issue 2, 2019
From the journal:

Organic Chemistry Frontiers

Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus†

Guozhang Lu,a   Jun Chen,b   Xinlei Huangfu,a   Xueyan Li,a   Meijuan Fang, ORCID logo *b   Guo Tang ORCID logo *a  and  Yufen Zhao ORCID logo a  

* Corresponding authors

a Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China
E-mail: t12g21@xmu.edu.cn

b School of Pharmaceutical Sciences and the Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361005, China
E-mail: fangmj@xmu.edu.cn

Abstract

A light-promoted phosphorylation of thiols from P4 is described. The reaction of P4 with arylthiols in the presence of Na2–eosin Y under visible light gave phosphorotrithioites. Subsequent oxidation of phosphorotrithioites produced phosphorotrithioates. The phosphorotrithioate 3f presents good inflammation reducing characteristics.

Graphical abstract: Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus

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Article information

DOI
https://doi.org/10.1039/C8QO01087K
Article type
Research Article
Submitted
10 Oct 2018
Accepted
16 Nov 2018
First published
16 Nov 2018

Org. Chem. Front., 2019,6, 190-194

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Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus

G. Lu, J. Chen, X. Huangfu, X. Li, M. Fang, G. Tang and Y. Zhao, Org. Chem. Front., 2019, 6, 190 DOI: 10.1039/C8QO01087K

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