Jump to main content
Jump to site search

Issue 2, 2019
Previous Article Next Article

N-Heterocyclic carbene catalyzed chemo- and enantioselective cross-benzoin reaction of aldehydes with isatins

Author affiliations

Abstract

A highly chemoselective intermolecular cross-benzoin reaction of aldehydes with isatins enabled by asymmetric N-heterocyclic carbene (NHC) catalysis is described, and it provides 3-substituted-3-hydroxyoxindoles in moderate to good yields with moderate to excellent enantioselectivities. This reaction can be readily scaled up, the products could be straightforwardly reduced to the corresponding 1,2-diols, and the trityl (Trt) protecting group could be easily removed without erosion of enantioselectivities.

Graphical abstract: N-Heterocyclic carbene catalyzed chemo- and enantioselective cross-benzoin reaction of aldehydes with isatins

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Oct 2018, accepted on 21 Nov 2018 and first published on 22 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QO01085D
Citation: Org. Chem. Front., 2019,6, 172-176

  •   Request permissions

    N-Heterocyclic carbene catalyzed chemo- and enantioselective cross-benzoin reaction of aldehydes with isatins

    J. Xu, J. Peng, C. He and H. Ren, Org. Chem. Front., 2019, 6, 172
    DOI: 10.1039/C8QO01085D

Search articles by author

Spotlight

Advertisements