Issue 23, 2018

Rh(iii)-Catalyzed α-fluoroalkenylation of N-nitrosoanilines with 2,2-difluorovinyl tosylates via C–H bond activation

Abstract

Rh(III)-Catalyzed α-fluoroalkenylation of N-nitrosoanilines with 2,2-difluorovinyl tosylates has been realized. This reaction proceeded via chelation-assisted C–H activation, olefin insertion and β-F elimination, leading to the synthesis of monofluoroalkenes with high Z-selectivity with respect to the olefin. This catalytic system is highly efficient over a broad range of substrates under mild and redox-neutral conditions.

Graphical abstract: Rh(iii)-Catalyzed α-fluoroalkenylation of N-nitrosoanilines with 2,2-difluorovinyl tosylates via C–H bond activation

Supplementary files

Article information

Article type
Research Article
Submitted
01 Sep 2018
Accepted
09 Oct 2018
First published
18 Oct 2018

Org. Chem. Front., 2018,5, 3406-3409

Rh(III)-Catalyzed α-fluoroalkenylation of N-nitrosoanilines with 2,2-difluorovinyl tosylates via C–H bond activation

M. Tian, X. Yang, B. Zhang, B. Liu and X. Li, Org. Chem. Front., 2018, 5, 3406 DOI: 10.1039/C8QO00947C

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