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Issue 19, 2018
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A triple-functionalised metal centre-catalyzed enantioselective multicomponent reaction

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Abstract

An enantioselective multi-component reaction (MCR) was exquisitely developed by using a catalytic model of a triple-functionalised metal centre in a RhI/(DHQ)2PHAL system via multiple coordination interactions. The catalytic reactivity of the RhI centres was critically modulated by a complex dissociation process rather than a common ligand exchange process. The developed MCR offers a mild, atom-efficient, and step-economical method to construct 3,3-disubstituted oxindoles with high diastereo- and enantioselectivities. This study provides an efficient example that gives insight into a strategy for the discovery of MCRs by using high-coordination-number transition metals as multiple functional catalytic centres.

Graphical abstract: A triple-functionalised metal centre-catalyzed enantioselective multicomponent reaction

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Publication details

The article was received on 11 Jul 2018, accepted on 17 Aug 2018 and first published on 20 Aug 2018


Article type: Research Article
DOI: 10.1039/C8QO00703A
Org. Chem. Front., 2018,5, 2799-2804

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    A triple-functionalised metal centre-catalyzed enantioselective multicomponent reaction

    Q. Wei, X. Ma, J. Chen, L. Niu, X. Yang, F. Xia and S. Liu, Org. Chem. Front., 2018, 5, 2799
    DOI: 10.1039/C8QO00703A

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