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Issue 20, 2018
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One-pot transition-metal free transamidation to sterically hindered amides

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Abstract

One-pot synthesis of a variety of amides including sterically hindered amides from primary amides catalyzed by cesium fluoride has been developed for the first time. Primary amides provided sterically hindered amides in good yields (up to 86%), by transamidation, catalyzed by cesium fluoride, after a simple Boc-activation.

Graphical abstract: One-pot transition-metal free transamidation to sterically hindered amides

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Publication details

The article was received on 14 Jun 2018, accepted on 10 Sep 2018 and first published on 11 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00591E
Citation: Org. Chem. Front., 2018,5, 2950-2954

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    One-pot transition-metal free transamidation to sterically hindered amides

    W. Guo, J. Huang, H. Wu, T. Liu, Z. Luo, J. Jian and Z. Zeng, Org. Chem. Front., 2018, 5, 2950
    DOI: 10.1039/C8QO00591E

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