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Issue 16, 2018
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A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

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Abstract

We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1,2,3-triazoles via an oxidative interrupted click reaction, using air as the sole terminal oxidant. The current protocol provides a novel method for the one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as aromatic sources to interrupt the cuprate–triazole intermediate for the first time.

Graphical abstract: A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

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Publication details

The article was received on 13 Jun 2018, accepted on 03 Jul 2018 and first published on 04 Jul 2018


Article type: Research Article
DOI: 10.1039/C8QO00590G
Citation: Org. Chem. Front., 2018,5, 2463-2467

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    A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

    X. Yu, J. Xu, Y. Zhou and Q. Song, Org. Chem. Front., 2018, 5, 2463
    DOI: 10.1039/C8QO00590G

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