Access to sulfonylated furans or imidazo[1,2-a]pyridines via a metal-free three-component, domino reaction

Zhiming Cui; Baofu Zhu; Xuechen Li; Hua Cao

doi:10.1039/C8QO00443A

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Access to sulfonylated furans or imidazo[1,2-a]pyridines via a metal-free three-component, domino reaction†

Zhiming Cui,^a Baofu Zhu,^a Xuechen Li

*^b and Hua Cao

*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, P. R. China
E-mail: caohua@gdpu.edu.cn
Fax: +86 (760) 88207939

^b Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
E-mail: xuechenl@hku.hk

Abstract

An efficient three-component reaction of 1,3-dicarbonyl compounds or pyridin-2-amines with ynals and sodium benzenesulfinates has been developed. This domino process provides a new and effective strategy for the preparation of sulfonylated furan or imidazo[1,2-a]pyridine derivatives. The strategy exhibits excellent functional group tolerance and good efficiency.

This article is part of the themed collection: Organic Chemistry Frontiers HOT articles for 2018

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Article information

DOI: https://doi.org/10.1039/C8QO00443A
Article type: Research Article
Submitted: 02 May 2018
Accepted: 13 Jun 2018
First published: 14 Jun 2018

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Org. Chem. Front., 2018,5, 2219-2223

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Access to sulfonylated furans or imidazo[1,2-a]pyridines via a metal-free three-component, domino reaction

Z. Cui, B. Zhu, X. Li and H. Cao, Org. Chem. Front., 2018, 5, 2219 DOI: 10.1039/C8QO00443A

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Organic Chemistry Frontiers

Access to sulfonylated furans or imidazo[1,2-a]pyridines via a metal-free three-component, domino reaction†

Abstract

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Access to sulfonylated furans or imidazo[1,2-a]pyridines via a metal-free three-component, domino reaction

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