Decarboxylative formylation of aryl halides with glyoxylic acid by merging organophotoredox with palladium catalysis

Abstract

Decarboxylative formylation of aryl and heteroaryl halides with glyoxylic acid is enabled by synergistic catalysis using an organic dye, 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN), and a phosphine ligated palladium catalyst under mild irradiation conditions. A wide range of aryl halides and heteroaryl halides are amenable to deliver functionalized aryl and heteroaryl aldehydes. The reaction represents a new application of organophotoredox/palladium synergistic catalysis for catalytic decarboxylative cross-couplings.