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Issue 8, 2018
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Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

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Abstract

Visible light, in combination with the molecular iodine catalyst-mediated α-hydroxylation of α-methylene ketones, has been developed. The reaction proceeds smoothly in methanol at room temperature under aerobic conditions and shows exclusive selectivity toward methylene ketones. Mechanistic studies have revealed that the reaction proceeds by a radical pathway. Renewable energy, metal-free catalyst and abundant oxygen source alongside a wide scope and novel selectivity are features that make this strategy practical and eco-friendly.

Graphical abstract: Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

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Article information


Submitted
18 Jan 2018
Accepted
22 Feb 2018
First published
23 Feb 2018

Org. Chem. Front., 2018,5, 1325-1329
Article type
Research Article

Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

J. Yang, D. Xie, H. Zhou, S. Chen, C. Huo and Z. Li, Org. Chem. Front., 2018, 5, 1325
DOI: 10.1039/C8QO00056E

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