nBu4NOTf-promoted radical self-hydrogen transferring isomerization under transition metal-free conditions†
We report the first allylic isomerization of alcohols catalyzed by nBu4NOTf generated in situ from tetrabutylammonium triflate and potassium tert-butoxide. Substituted ketones could be prepared under mild conditions in good to excellent yields. The relationship between catalysts and their reactivity has been investigated by systematic kinetic studies. The radical nature of this isomerization reaction has also been confirmed.
- This article is part of the themed collection: Organic Chemistry Frontiers HOT articles for 2018