Issue 4, 2018
From the journal:

Organic Chemistry Frontiers

Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids†

Clovis Peter,a   Philippe Geoffroya  and  Michel Miesch ORCID logo *a  

* Corresponding authors

a Université de Strasbourg, Institut de Chimie, UMR CNRS/UdS 7177, 4 rue Blaise Pascal, CS 90032, 67081 Strasbourg-Cedex, France
E-mail: m.miesch@unistra.fr

Abstract

The Brønsted/Lewis acid catalyzed reaction of pyrrolidone, piperidone and isoindolinone derivatives tethered to α,β-unsaturated ketones or aldehydes afforded exclusively polyfunctionalized 1,3-oxazines with high diastereoselectivities and in high yields.

Graphical abstract: Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

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Article information

DOI
https://doi.org/10.1039/C7QO00891K
Article type
Research Article
Submitted
29 Sep 2017
Accepted
25 Oct 2017
First published
26 Oct 2017

Org. Chem. Front., 2018,5, 566-570

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Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

C. Peter, P. Geoffroy and M. Miesch, Org. Chem. Front., 2018, 5, 566 DOI: 10.1039/C7QO00891K

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