Issue 5, 2018

Photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation for synthesis of lactones under oxidant- and acceptor-free conditions

Abstract

A practical photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation is described herein, with dihydrogen as the only by-product. A variety of lactone products can be successfully constructed under oxidant- and acceptor-free conditions with good functional group tolerance and high yield. This protocol also provides a facile route to remote hydroxylated arenes and chromene.

Graphical abstract: Photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation for synthesis of lactones under oxidant- and acceptor-free conditions

Supplementary files

Article information

Article type
Research Article
Submitted
04 Sep 2017
Accepted
06 Nov 2017
First published
07 Nov 2017

Org. Chem. Front., 2018,5, 749-752

Photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation for synthesis of lactones under oxidant- and acceptor-free conditions

M. Zhang, R. Ruzi, N. Li, J. Xie and C. Zhu, Org. Chem. Front., 2018, 5, 749 DOI: 10.1039/C7QO00795G

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