Issue 8, 2017

Manganese-mediated/-catalyzed oxidative carboazidation of acrylamides

Abstract

Manganese-mediated/-catalyzed oxidative carboazidation of acrylamides was developed for the synthesis of various azido oxindoles in 32% to 99% yields. tert-Butyl peroxybenzoate (TBPB) was used as an oxidant for the Mn-catalyzed method. And a Mn(II)/Mn(IV)/Mn(III) catalysis cycle via a stepwise or concerted regeneration of high-valent manganese was proposed for this protocol. This reaction system exhibits great functional group tolerance.

Graphical abstract: Manganese-mediated/-catalyzed oxidative carboazidation of acrylamides

Supplementary files

Article information

Article type
Research Article
Submitted
18 Mar 2017
Accepted
03 May 2017
First published
04 May 2017

Org. Chem. Front., 2017,4, 1555-1560

Manganese-mediated/-catalyzed oxidative carboazidation of acrylamides

D. Zhao, K. Kang, W. Wan, H. Jiang, H. Deng, Y. Chen and J. Hao, Org. Chem. Front., 2017, 4, 1555 DOI: 10.1039/C7QO00217C

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