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Issue 1, 2017
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A facile approach for the trifluoromethylthiolation of methylenecyclopropanes

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Abstract

A facile approach for the trifluoromethylthiolation of methylenecyclopropanes (MCPs) has been developed by using AgSCF3/Na2S2O8 as a trifluoromethylthiolation source (SCF3) to give trifluoromethylthiolated 1,2-dihydro-naphthalene derivatives in moderate to good yields, and the reaction has been proven to go through a radical-type pathway. The products can easily be aromatized upon oxidation, offering a new method for the construction of trifluoromethylthiolated naphthalenes.

Graphical abstract: A facile approach for the trifluoromethylthiolation of methylenecyclopropanes

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Article information


Submitted
12 Sep 2016
Accepted
19 Oct 2016
First published
20 Oct 2016

Org. Chem. Front., 2017,4, 86-90
Article type
Research Article

A facile approach for the trifluoromethylthiolation of methylenecyclopropanes

M. Chen, X. Tang and M. Shi, Org. Chem. Front., 2017, 4, 86
DOI: 10.1039/C6QO00536E

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