Issue 7, 2016

Catalytic one-pot synthesis of 4-(hetero)aryl substituted 5-(2-oxoethyl) oxazol-2(3H)-ones by coupling–isomerization–elimination (CIE) sequence

Abstract

N-Boc protected 1-aryl propargyl carbamates and acid chlorides can be readily transformed in a one-pot fashion by a coupling–isomerization–elimination (CIE) sequence into 4-substituted 5-(2-oxoethyl) oxazol-2(3H)-ones in moderate to good yield.

Graphical abstract: Catalytic one-pot synthesis of 4-(hetero)aryl substituted 5-(2-oxoethyl) oxazol-2(3H)-ones by coupling–isomerization–elimination (CIE) sequence

Supplementary files

Article information

Article type
Research Article
Submitted
01 Apr 2016
Accepted
19 May 2016
First published
19 May 2016
This article is Open Access
Creative Commons BY license

Org. Chem. Front., 2016,3, 887-896

Catalytic one-pot synthesis of 4-(hetero)aryl substituted 5-(2-oxoethyl) oxazol-2(3H)-ones by coupling–isomerization–elimination (CIE) sequence

C. Görgen née Boersch, K. Lutsenko, E. Merkul, W. Frank and T. J. J. Müller, Org. Chem. Front., 2016, 3, 887 DOI: 10.1039/C6QO00138F

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