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Issue 4, 2016
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Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

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Abstract

A novel gold-catalyzed tandem alkyne amination/intramolecular O–H insertion has been developed. A variety of [1,4]oxazino[3,2-c]isoquinolines are readily accessed under mild reaction conditions by utilizing this strategy, thereby providing an efficient and practical route for the construction of synthetically useful fused isoquinolines.

Graphical abstract: Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

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Article information


Submitted
20 Jan 2016
Accepted
12 Feb 2016
First published
12 Feb 2016

Org. Chem. Front., 2016,3, 491-495
Article type
Research Article

Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

Y. Pan, G. Chen, C. Shen, W. He and L. Ye, Org. Chem. Front., 2016, 3, 491
DOI: 10.1039/C6QO00033A

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