Cu-catalyzed sp3 C–H bond oxidative functionalization of alkylazaarenes and substituted ethanones: an efficient approach to isoxazoline derivatives

Gang-Wei Wang; Shi-Xia Li; Quan-Xiang Wu; Shang-Dong Yang

doi:10.1039/C5QO00053J

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Cu-catalyzed sp³ C–H bond oxidative functionalization of alkylazaarenes and substituted ethanones: an efficient approach to isoxazoline derivatives†

Gang-Wei Wang,‡^a Shi-Xia Li,‡^a Quan-Xiang Wu^a and Shang-Dong Yang*^ab

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* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China
E-mail: yangshd@lzu.edu.cn
Fax: +86-931-8912859
Tel: +86-931-8912859

^b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Lanzhou 730000, P. R. China

Abstract

Cu-catalyzed sp³ C–H bond oxidative functionalization of alkylazaarenes and substituted ethanones to different kinds of isoxazoline derivatives by 1,3-dipolar cycloaddition is reported. Cheap sources of nitro, commercially available substrates, as well as a variety of alkenes (alkynes) are applied in this transformation.

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Article information

DOI: https://doi.org/10.1039/C5QO00053J
Article type: Research Article
Submitted: 13 Feb 2015
Accepted: 26 Mar 2015
First published: 27 Mar 2015

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Org. Chem. Front., 2015,2, 569-573

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Cu-catalyzed sp³ C–H bond oxidative functionalization of alkylazaarenes and substituted ethanones: an efficient approach to isoxazoline derivatives

G. Wang, S. Li, Q. Wu and S. Yang, Org. Chem. Front., 2015, 2, 569 DOI: 10.1039/C5QO00053J

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