Issue 7, 2015
From the journal:

Organic Chemistry Frontiers

A challenging Heck reaction of maleimides†

Li Hui Lima  and  Jianrong (Steve) Zhou*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371
E-mail: jrzhou@ntu.edu.sg
Fax: (+65) 67911961

Abstract

Maleimides are extremely susceptible to basic hydrolysis and gave poor yields under Heck conditions. The longstanding problem is solved with the use of a weak base KOAc in a carbonate solvent.

Graphical abstract: A challenging Heck reaction of maleimides

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Article information

DOI
https://doi.org/10.1039/C5QO00015G
Article type
Research Article
Submitted
13 Jan 2015
Accepted
15 Apr 2015
First published
16 Apr 2015

Org. Chem. Front., 2015,2, 775-777

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A challenging Heck reaction of maleimides

L. H. Lim and J. (. Zhou, Org. Chem. Front., 2015, 2, 775 DOI: 10.1039/C5QO00015G

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