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Issue 5, 2014
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Highly enantioselective oxidative tandem cyclization reaction: a chiral ligand and an anion cooperatively control stereoselectivity

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Abstract

The unprecedented combination of a palladium(II) complex with a chiral Bu-QUOX ligand and a chiral phosphoric acid enables the highly efficient asymmetric oxidative tandem cyclization of N-(2,2-disubstituted hex-5-en-1-yl)acrylamides, providing a straightforward method to access chiral 6,5-bicyclic aza-heterocycles in moderate to good yields and with excellent enantioselectivities.

Graphical abstract: Highly enantioselective oxidative tandem cyclization reaction: a chiral ligand and an anion cooperatively control stereoselectivity

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Article information


Submitted
15 Feb 2014
Accepted
24 Mar 2014
First published
25 Mar 2014

Org. Chem. Front., 2014,1, 473-476
Article type
Research Article
Author version available

Highly enantioselective oxidative tandem cyclization reaction: a chiral ligand and an anion cooperatively control stereoselectivity

Y. He, H. Wu, L. Xu, Y. Su and L. Gong, Org. Chem. Front., 2014, 1, 473
DOI: 10.1039/C4QO00042K

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