Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(I) complex of a monodentate secondary phosphine oxide ligand

Kaiwu Dong; Yang Li; Zheng Wang; Kuiling Ding

doi:10.1039/C3QO00042G

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Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand†

Kaiwu Dong,^a Yang Li,^a Zheng Wang^a and Kuiling Ding*^a

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* Corresponding authors

^a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China
E-mail: kding@mail.sioc.ac.cn
Fax: +86-21-6416-6128
Tel: +86-21-5492-5146

Abstract

The Rh^I complexes of chiral secondary phosphine oxide ligands have been disclosed to be efficient for the catalytic asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids, providing the corresponding chiral α-arylpropanoic and β-arylbutanoic acids in excellent yields with up to 97% ee, including several anti-inflammatory drugs.

This article is part of the themed collection: Celebrating 70 Years of Shanghai Institute of Organic Chemistry

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Article information

DOI: https://doi.org/10.1039/C3QO00042G
Article type: Research Article
Submitted: 18 Nov 2013
Accepted: 12 Jan 2014
First published: 24 Jan 2014

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Org. Chem. Front., 2014,1, 155-160

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Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(I) complex of a monodentate secondary phosphine oxide ligand

K. Dong, Y. Li, Z. Wang and K. Ding, Org. Chem. Front., 2014, 1, 155 DOI: 10.1039/C3QO00042G

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Organic Chemistry Frontiers

Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand†

Abstract

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Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(I) complex of a monodentate secondary phosphine oxide ligand

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