Issue 1, 2014
From the journal:

Organic Chemistry Frontiers

Scalable, efficient total synthesis of (+)-mupirocin H†

Changgui Zhao,a   Ziyun Yuan,a   Yuanyuan Zhang,a   Bin Ma,a   Huilin Li,a   Shouchu Tang,a   Xingang Xie*a  and  Xuegong She*ab  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China
E-mail: xiexg@lzu.edu.cn, shexg@lzu.edu.cn
Fax: +86-931-8912582

b State Key Laboratory of Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, P. R. China

Abstract

A scalable, efficient total synthesis of mupirocin H was accomplished in 7 longest linear steps with 39% overall yield. The developed strategy is great progress for the construction of pseudomonic acid analogues and all steps in our strategy could be conducted on a gram scale. The strategy is also suitable for other related molecules.

Graphical abstract: Scalable, efficient total synthesis of (+)-mupirocin H

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Article information

DOI
https://doi.org/10.1039/C3QO00038A
Article type
Research Article
Submitted
14 Nov 2013
Accepted
02 Dec 2013
First published
23 Dec 2013

Org. Chem. Front., 2014,1, 105-108

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Scalable, efficient total synthesis of (+)-mupirocin H

C. Zhao, Z. Yuan, Y. Zhang, B. Ma, H. Li, S. Tang, X. Xie and X. She, Org. Chem. Front., 2014, 1, 105 DOI: 10.1039/C3QO00038A

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