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Issue 7, 2020

Rapid, ultrasensitive and highly specific biosensor for the diagnosis of SARS-CoV-2 in clinical blood samples

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Abstract

In this study, a lateral flow combined IgG–IgM immunochromatographic assay is developed for the rapid, simultaneous detection of IgM and IgG antibodies against SARS-CoV-2 in clinical blood samples within 15 min. The clinical detection sensitivity and specificity of the assay strips is investigated in samples of blood from inpatients with COVID-19. The sensitivity and specificity of this assay are 85.29% and 100.00%, respectively. Compared with a single IgG and IgM test, the combined IgG–IgM immunochromatographic strip test has higher sensitivity. Our results demonstrate that the combined IgG–IgM immunochromatographic strip is suitable for the rapid screening of SARS-CoV-2 infection, among confirmed COVID-19 patients, suspect patients and asymptomatic SARS-CoV-2 carriers.

Graphical abstract: Rapid, ultrasensitive and highly specific biosensor for the diagnosis of SARS-CoV-2 in clinical blood samples

Article information


Submitted
03 May 2020
Accepted
29 May 2020
First published
29 May 2020

Mater. Chem. Front., 2020,4, 2000-2005
Article type
Research Article

Rapid, ultrasensitive and highly specific biosensor for the diagnosis of SARS-CoV-2 in clinical blood samples

L. Zeng, Y. Li, J. Liu, L. Guo, Z. Wang, X. Xu, S. Song, C. Hao, L. Liu, M. Xin and C. Xu, Mater. Chem. Front., 2020, 4, 2000 DOI: 10.1039/D0QM00294A

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