Issue 6, 2021

Fluorescent polymers via post-polymerization modification of Biginelli-type polymers for cellular protection against UV damage

Abstract

The development of biofriendly UV-protective materials is important because current UV-screening inorganic nanoparticles and organic small molecules have potential safety risks. In this research, new polymers with dramatic UV-protective capabilities have been effectively prepared through post-polymerization modification (PPM) of a Biginelli-type copolymer. The resulting polymers are fluorescent because of the heterocyclic structures generated by PPM; thus, the endocytosis of these polymers could be easily detected. The conjugated polymers obtained by the PPM method present low cytotoxicity and are superior to the unconjugated original Biginelli-type polymer in preventing UV-induced DNA damage and cell necrosis. This work demonstrates that the combination of the Biginelli reaction with the PPM method is a viable strategy for developing biocompatible UV-protective polymers for practical applications.

Graphical abstract: Fluorescent polymers via post-polymerization modification of Biginelli-type polymers for cellular protection against UV damage

Supplementary files

Article information

Article type
Paper
Submitted
06 Apr 2020
Accepted
06 Jan 2021
First published
14 Jan 2021

Polym. Chem., 2021,12, 852-857

Fluorescent polymers via post-polymerization modification of Biginelli-type polymers for cellular protection against UV damage

T. Mao, X. He, G. Liu, Y. Wei, Y. Gou, X. Zhou and L. Tao, Polym. Chem., 2021, 12, 852 DOI: 10.1039/D0PY00503G

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