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Issue 36, 2019
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Multi-stimuli responsive trigger for temporally controlled depolymerization of self-immolative polymers

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Abstract

For many decades, stimuli-responsive materials have been studied and utilized in various fields, ranging from chemical sensors to controlled drug release. Among these responsive materials are self-immolative polymers (SIPs) that allow for end-to-end depolymerization and the ability to release a desired cargo on demand or amplify analyte detection. However, in typical SIP systems, the triggering event leads to a relatively uncontrolled degradation process. Herein we present a multi-stimuli trigger that utilizes the combination of heat and acid to impart control over the trigger event and thus the degradation process. By controlling this reaction, we achieve temporal control over the trigger cleavage and subsequent depolymerization and release of cargo from the SIP.

Graphical abstract: Multi-stimuli responsive trigger for temporally controlled depolymerization of self-immolative polymers

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Article information


Submitted
24 Feb 2019
Accepted
09 Aug 2019
First published
12 Aug 2019

Polym. Chem., 2019,10, 4914-4919
Article type
Communication

Multi-stimuli responsive trigger for temporally controlled depolymerization of self-immolative polymers

M. F. Nichol, K. D. Clark, N. D. Dolinski and J. Read de Alaniz, Polym. Chem., 2019, 10, 4914
DOI: 10.1039/C9PY00301K

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