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Issue 23, 2019
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Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles

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Abstract

Antifreeze proteins (AFPs) have many potential applications, ranging from cryobiology to aerospace, if they can be incorporated into materials. Here, a range of engineered AFP mutants were prepared and site-specifically conjugated onto RAFT polymer-stabilized gold nanoparticles to generate new hybrid multivalent ice growth inhibitors. Only the SNAP-tagged AFPs lead to potent ‘antifreeze’ active nanomaterials with His-Tag capture resulting in no activity, showing the mode of conjugation is essential. This versatile strategy will enable the development of multivalent AFPs for translational and fundamental studies.

Graphical abstract: Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles

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Supplementary files

Article information


Submitted
03 Dec 2018
Accepted
21 Jan 2019
First published
31 Jan 2019

This article is Open Access

Polym. Chem., 2019,10, 2986-2990
Article type
Communication

Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles

L. E. Wilkins, M. Hasan, A. E. R. Fayter, C. Biggs, M. Walker and M. I. Gibson, Polym. Chem., 2019, 10, 2986
DOI: 10.1039/C8PY01719K

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    [Original citation] - Published by The Royal Society of Chemistry.

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