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Issue 23, 2019
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Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles

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Abstract

We report the one-pot aqueous phase synthesis of cisplatin drug loaded micellar nanoparticles using Ring-Opening Metathesis Polymerization-Induced Self-Assembly (ROMPISA). ROMPISA was used to generate a small library of nanoparticles to examine the effect of size and charge on their action as cytotoxic agents against human ovarian and cervical cancer cells in vitro. The results show that polymerization-induced self-assembly (PISA) can easily yield drug loaded nanoparticles in one step at high solids concentrations in water for formulation of drugs at cytotoxic levels.

Graphical abstract: Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles

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Article information


Submitted
29 Oct 2018
Accepted
25 Mar 2019
First published
25 Apr 2019

Polym. Chem., 2019,10, 2996-3000
Article type
Communication
Author version available

Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles

D. B. Wright, M. T. Proetto, M. A. Touve and N. C. Gianneschi, Polym. Chem., 2019, 10, 2996
DOI: 10.1039/C8PY01539B

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