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Issue 1, 2018
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In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering

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Abstract

We report a biocompatible and in situ cross-linkable hydrogel derived from hyaluronic acid via a bioorthogonal reaction and confirm the clinical potential of our hydrogel through in vivo cartilage regeneration. Gelation is attributed to copper-free click reactions between an azide and dibenzyl cyclooctyne. HA-PEG4-DBCO was synthesized and cross-linked via 4-arm PEG azide. The effects of the ratio of HA-PEG4-DBCO to 4-arm PEG azide on the gelation time, microstructure, surface morphology, equilibrium swelling, and compressive modulus were examined. The potential of a hydrogel as an injectable scaffold was demonstrated by the encapsulation of chondrocytes within the hydrogel matrix in vitro and in vivo. The results demonstrated that the hydrogel supported cell survival, and the cells regenerated cartilaginous tissue. In addition, these characteristics provide potential opportunities for the use of injectable hydrogels in tissue engineering applications.

Graphical abstract: In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering

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Supplementary files

Article information


Submitted
26 Sep 2017
Accepted
23 Oct 2017
First published
25 Oct 2017

Polym. Chem., 2018,9, 20-27
Article type
Paper

In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering

S. Han, H. Y. Yoon, J. Y. Yhee, M. O. Cho, H. Shim, J. Jeong, D. Lee, K. Kim, H. Guim, J. H. Lee, K. M. Huh and S. Kang, Polym. Chem., 2018, 9, 20
DOI: 10.1039/C7PY01654A

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