Issue 45, 2017

Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

Abstract

It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene (PPZ) onto multi-walled carbon nanotubes (MWNTs) via one-pot in situ polymerization of doxorubicin (DOX) and bis-(4-hydroxyphenyl)-disulfide (HPS) with hexachlorocyclotriphosphazene. The DOX loading ratio and release rate were precisely tuned via the adjustment of the DOX to HPS molar ratio. MWNTs were used as a nanotemplate and near-infrared photothermal conversion agent for effective photothermal therapy. Remarkably, this multifunctional DDS selectively suppressed and killed cancer cells, but negligibly affected normal cells. Hence, this DDS demonstrates the proof-of-concept for effective chemo-photothermal synergistic therapy.

Graphical abstract: Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2017
Accepted
01 Oct 2017
First published
03 Oct 2017

Polym. Chem., 2017,8, 6938-6942

Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

D. Wang, Y. Ren, Y. Shao and L. Meng, Polym. Chem., 2017, 8, 6938 DOI: 10.1039/C7PY01485F

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