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Issue 38, 2017
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Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

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Abstract

A series of mitochondria-targeting amphipathic prodrugs were developed and subsequently the relationship of different locations of TPP modification and molecular weights of mPEG for selective imaging and therapeutic targeting were tested. The aqueous self-assembled micelles can realize controlled release of free drug, with a faster release at alkaline pH.

Graphical abstract: Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

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Article information


Submitted
08 Jul 2017
Accepted
08 Aug 2017
First published
09 Aug 2017

Polym. Chem., 2017,8, 5982-5987
Article type
Paper

Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency

B. Liu, W. Wu, Y. Liu, C. Jia, X. Yang, J. Li, N. Wang and X. Yu, Polym. Chem., 2017, 8, 5982
DOI: 10.1039/C7PY01138E

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