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Issue 5, 2017
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Polypeptides by light: photo-polymerization of N-carboxyanhydrides (NCA)

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Abstract

The synthesis of polypeptides by N-carboxyanhydride (NCA) photopolymerization is demonstrated. The active initiator cyclohexylamine was produced in situ by the UV-induced breakdown of photoamine generators. Real-time FTIR and MALDI-ToF-MS analyses provide clear evidence for the proposed photoinitiation mechanism as well as the attachment of the active initiator to the polypeptide chain. NCA photopolymerization generates new possibilities for designing polypeptides both in solution and on surfaces.

Graphical abstract: Polypeptides by light: photo-polymerization of N-carboxyanhydrides (NCA)

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Publication details

The article was received on 18 Nov 2016, accepted on 20 Dec 2016 and first published on 21 Dec 2016


Article type: Communication
DOI: 10.1039/C6PY02018F
Citation: Polym. Chem., 2017,8, 828-832

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    Polypeptides by light: photo-polymerization of N-carboxyanhydrides (NCA)

    T. Stukenkemper, J. F. G. A. Jansen, C. Lavilla, A. A. Dias, D. F. Brougham and A. Heise, Polym. Chem., 2017, 8, 828
    DOI: 10.1039/C6PY02018F

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