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Issue 28, 2015
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A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin

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Abstract

An acid-labile and PEGylated polyphosphoester-doxorubicin prodrug (PBYP-g-PEG-g-DOX) was prepared via a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry. The resulting multifunctional prodrug was then used to interact with α-cyclodextrin (α-CD) to fabricate a novel supramolecular hydrogel based on inclusion complexation.

Graphical abstract: A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin

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Supplementary files

Article information


Submitted
28 Apr 2015
Accepted
02 Jun 2015
First published
03 Jun 2015

Polym. Chem., 2015,6, 5009-5014
Article type
Communication

A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin

F. Li, J. He, M. Zhang and P. Ni, Polym. Chem., 2015, 6, 5009 DOI: 10.1039/C5PY00620A

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