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Issue 24, 2014
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Ultra bright red AIE dots for cytoplasm and nuclear imaging

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Abstract

An aggregation-induced emission (AIE) molecule (2-(2,6-bis((E)-2-(5-(N,N-bis(4-((E)-2-(10-((E)-4-(diphenylamino)styryl)anthracen-9-yl)vinyl)phenyl)aniline-4-yl)thiophen-2-yl)vinyl)-4H-pyran-4-ylidene)malononitrile) (TPA-AN-TPM) with near-infrared emission was synthesized by coating a disc-like red emission fluorophore with a propeller-shaped AIE fluorophore. The ultrabright red AIE dots TPA-AN-TPM@PS-PVP (TPA-AN-TPM in poly(styrene)-poly(4-vinylpyridine) nanoparticles) with an absolute quantum yield of 12.9% were fabricated by using the AIE molecule TPA-AN-TPM as the core and one biocompatible polymer PS-PVP as the encapsulation matrix. The AIE dots are mono-dispersed with an average diameter of 25 nm, and are stable in an aqueous suspension. In particular, the AIE dots can stain both the cytoplasm and the nuclei with a strong red fluorescence signal, and pose little toxicity to living cells.

Graphical abstract: Ultra bright red AIE dots for cytoplasm and nuclear imaging

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Publication details

The article was received on 31 May 2014, accepted on 13 Aug 2014 and first published on 13 Aug 2014


Article type: Paper
DOI: 10.1039/C4PY00764F
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Citation: Polym. Chem., 2014,5, 7013-7020
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    Ultra bright red AIE dots for cytoplasm and nuclear imaging

    Z. Wang, L. Yan, L. Zhang, Y. Chen, H. Li, J. Zhang, Y. Zhang, X. Li, B. Xu, X. Fu, Z. Sun and W. Tian, Polym. Chem., 2014, 5, 7013
    DOI: 10.1039/C4PY00764F

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