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Issue 19, 2014
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Innovative well-defined primary amine-based polyacrylates for plasmid DNA complexation

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Abstract

Well-defined quaternized poly(2-aminoethyl acrylate)s (qPAEAs) have been synthesized by RAFT polymerization of N-(tert-butoxycarbonyl)aminoethyl acrylate (t-BocAEA) followed by t-Boc group deprotection. The ability of qPAEAs to act as potential “smart” DNA carriers has been shown by plasmid DNA/qPAEA complexation and qPAEA degradation in water at 37 °C without any trigger.

Graphical abstract: Innovative well-defined primary amine-based polyacrylates for plasmid DNA complexation

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Publication details

The article was received on 28 Apr 2014, accepted on 27 May 2014 and first published on 16 Jun 2014


Article type: Communication
DOI: 10.1039/C4PY00585F
Polym. Chem., 2014,5, 5542-5545

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    Innovative well-defined primary amine-based polyacrylates for plasmid DNA complexation

    H. T. Ho, S. Pascual, V. Montembault, N. Casse and L. Fontaine, Polym. Chem., 2014, 5, 5542
    DOI: 10.1039/C4PY00585F

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