Issue 17, 2014
From the journal:

Polymer Chemistry

Self-assembly of plasma protein through disulfide bond breaking and its use as a nanocarrier for lipophilic drugs†

Shudong Wang,a   Guangming Gong,*a   Hua Su,a   Wenya Liu,a   Zhen Wanga  and  Li Lia  

* Corresponding authors

a Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, People’s Republic of China
E-mail: wangshdong163@sina.com, gonggm@126.com
Tel: +86-25-80860161

Abstract

A disulfide bond breaking strategy used to fabricate HSA nanoparticles with dithiothreitol as the reducing agent is presented. The hydrophobic interaction is a dominating factor in the assembly process. These nanoparticles are suitable lipophilic drug delivery systems, which have significant tumor-targeting capabilities.

Graphical abstract: Self-assembly of plasma protein through disulfide bond breaking and its use as a nanocarrier for lipophilic drugs

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Article information

DOI
https://doi.org/10.1039/C4PY00212A
Article type
Communication
Submitted
14 Feb 2014
Accepted
03 May 2014
First published
16 May 2014

Polym. Chem., 2014,5, 4871-4874

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Self-assembly of plasma protein through disulfide bond breaking and its use as a nanocarrier for lipophilic drugs

S. Wang, G. Gong, H. Su, W. Liu, Z. Wang and L. Li, Polym. Chem., 2014, 5, 4871 DOI: 10.1039/C4PY00212A

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