Jump to main content
Jump to site search

Issue 4, 2014
Previous Article Next Article

Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers

Author affiliations

Abstract

Various click chemistry azide–alkyne cycloaddition reactions were used to attach azide group-terminated peptides to polymer drug carriers in an effort to conjugate biologically active molecules with polymer drug carriers by directly binding unprotected peptides to these polymers. Three methods using click chemistry to conjugate the azide group-containing molecules with synthetic polymers were compared: (1) click chemistry with a Cu(I) catalyst in aqueous and organic solvents, (2) click reactions using ruthenium complex catalysts in DMF and (3) metal-free click chemistry based on a dibenzocyclooctyne (DBCO) reactive group. The suitability of these reactions was verified for the non-covalent attachment of targeting moieties to these polymer carriers via peptide–peptide interactions. Moreover, RAFT polymerization was suggested for the synthesis of semitelechelic copolymers containing a single DBCO group at the polymer chain end and for the preparation of well-defined diblock copolymer drug carriers consisting of specific peptide and hydrophilic polymer blocks.

Graphical abstract: Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Oct 2013, accepted on 25 Oct 2013 and first published on 29 Oct 2013


Article type: Paper
DOI: 10.1039/C3PY01376F
Polym. Chem., 2014,5, 1340-1350

  •   Request permissions

    Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers

    R. Pola, A. Braunová, R. Laga, M. Pechar and K. Ulbrich, Polym. Chem., 2014, 5, 1340
    DOI: 10.1039/C3PY01376F

Search articles by author

Spotlight

Advertisements