Issue 5, 2014

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Abstract

We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50–100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

Graphical abstract: Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Supplementary files

Article information

Article type
Communication
Submitted
06 Sep 2013
Accepted
27 Sep 2013
First published
03 Oct 2013

Polym. Chem., 2014,5, 1581-1585

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Q. Yin, R. Tong, L. Yin, T. M. Fan and J. Cheng, Polym. Chem., 2014, 5, 1581 DOI: 10.1039/C3PY01245J

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