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Issue 2, 2014
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Cationic polythiophenes as responsive DNA-binding polymers

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Abstract

A new water soluble cationic polythiophene derivative, poly(N,N,N-trimethyl-3-(2-(thiophen-3-yl)acetamido)propan-1-aminium iodide), was synthesized via two consecutive post-polymerization functionalizations of poly(methyl 2-(thiophen-3-yl)acetate). This conjugated polymer binds DNA at N/P = 5 and forms polyplexes at N/P = 10. Its potential use as a theranostic gene delivery vehicle is investigated here.

Graphical abstract: Cationic polythiophenes as responsive DNA-binding polymers

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Supplementary files

Article information


Submitted
07 Aug 2013
Accepted
29 Aug 2013
First published
23 Sep 2013

This article is Open Access

Polym. Chem., 2014,5, 314-317
Article type
Communication

Cationic polythiophenes as responsive DNA-binding polymers

A. C. Carreon, W. L. Santos, J. B. Matson and R. C. So, Polym. Chem., 2014, 5, 314
DOI: 10.1039/C3PY01069D

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