Jump to main content
Jump to site search

Issue 8, 2011
Previous Article Next Article

Inverse thermally reversible gelation-based hydrogels: synthesis and characterization of N-isopropylacrylamide copolymers containing deoxycholic acid in the side chain

Author affiliations

Abstract

A series of water-soluble, thermosensitive copolymers based on N-isopropylacrylamide (NIPAM) and methacrylate derivatives of deoxycholic acid (MEDCA) were synthesized using free radical copolymerization method by varying feed ratios of monomers. The composition ratios and structure of copolymers were determined by 1H NMR spectroscopy. The glass transition temperature was examined by DSC. The thermoresponsive behaviors of polymeric solutions were investigated by turbidity measurement using UV-Visible spectroscopy. The resultant copolymers exhibit systematic changes in their LCSTs as a function of their chemical composition, as the incorporation of amphiphilic comonomers MEDCA results in a lower and broader LCST of the copolymer solution. An aqueous solution of the copolymer above a critical concentration (2 wt%) experiences four distinct phases such as clear solutions, cloud solutions, gel and shrunken gel upon heating. Finally, the mechanism of the phase transitions was tentatively discussed based on the observations.

Graphical abstract: Inverse thermally reversible gelation-based hydrogels: synthesis and characterization of N-isopropylacrylamide copolymers containing deoxycholic acid in the side chain

Back to tab navigation

Publication details

The article was received on 03 Mar 2011, accepted on 17 May 2011 and first published on 31 May 2011


Article type: Paper
DOI: 10.1039/C1PY00098E
Polym. Chem., 2011,2, 1866-1871

  •   Request permissions

    Inverse thermally reversible gelation-based hydrogels: synthesis and characterization of N-isopropylacrylamide copolymers containing deoxycholic acid in the side chain

    Y. Lu, Y. Han, J. Liang, H. Meng, F. Han, X. Wang and C. Li, Polym. Chem., 2011, 2, 1866
    DOI: 10.1039/C1PY00098E

Search articles by author

Spotlight

Advertisements